Quercetin particles with lower inhibitory activity for α-glycosidase and negligible effects on blood clotting

Poly(quercetin) (p(QR)) particles was synthesis by using poly(ethylene glycol) diglycidyl ether (PEGGE) crosslinker in a single step via microemulsion system. The morphological, size and functional analysis of the prepared were carried optic microscope, scanning electron microscope (SEM), dynamic light scattering (DLS) measurements FT-IR spectroscopy. P(QR) found to be spherical shape with 372±9 nm range means SEM images DLS measurements. zeta potential measurements, performed at different pH conditions potentiometric titration p(QR) revealed that isoelectric point pKa values as around 2.5 2.3, respectively. Ferric reducing antioxidant power (FRAP) determined for QR 3.6 9.4 0.43 µg reduced Fe(ll). effects on alfa-glycosidase enzyme activity 6.9 investigated molecules capable inhibiting α-glycosidase 89.3% 24.7% fluorescence spectroscopy fibrinogen showed do not induce clothing blood.